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Though tuberculin positivity was not affected by MTX intake in patients Table 3it was significantly lower in patients with recent steroid intake Group Ias compared to patients without any steroid intake within 3 months control S.
Interdisciplinary Perspectives on Infectious Diseases
There was no significant difference between control S and group II Table 4. Comparison of tuberculin sensitivity among patients taking different doses of methotrexate.
Comparison of tuberculin sensitivity among RA patients based on steroid exposure. A prospective study of serial tuberculin skin testing performed on patients from the chronic care wards of a Veterans Administration Hospital revealed a positive test in In a study in Taiwan, From India, Seal et al.
In our study, The study was done at a single centre in North India and may need to be replicated on multicentric study. Comparing the results from our study with the available population data, we can infer that presence of rheumatoid arthritis influences the results of tuberculin test in our population.
In a study from Italy also, prevalence of latent tuberculosis using TST, among patients suffering from immunomediated inflammatory diseases, was found to be Lower rates of TST positivity in RA may be attributable to the disease itself or the drugs used for its therapy. Another suggestion from this study was that there is no effect of MTX dose on the results of tuberculin test.
However, even the low doses of recent steroid intake significantly reduce the chances of tuberculin positivity. These results echo the results from the past studies.
- TB GOLD, INTERFERON GAMMA RELEASE ASSAY (IGRA)
A study carried out at Florence, Italy, revealed that the proportion of positive scoring for TST was significantly lower in patients on treatment with steroids compared with the proportion of positive results in patients who were not receiving treatment with steroids. However, it is not statistically significant due to small number of patients but should be explored further in view of its clinical importance. Provides opportunities for individually designed problems, work experiences, or research projects related to the quantlferon of professional competencies in a major field of study.
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